McDermott Lab

Tripathi S., Miyake T., Kelebeev J., McDermott JC. TAZ exhibits phase separation properties and interacts with Smad7 and β-catenin to repress skeletal myogenesis. J Cell Sci. 2021 Dec 3:jcs.259097. doi: 10.1242/jcs.259097. Online ahead of print.PMID: 34859820

Nucleolar localization of c-Jun. Miyake T., and McDermott JC. FEBS J. 2022.  Feb;289(3):748-765. doi: 10.1111/febs.16187. PMID: 34499807

Miyake, T., Aziz, A., and McDermott, J.C. Maintenance of the undifferentiated state in myogenic progenitor cells by TGFβ signaling is Smad independent and requires MEK Activation Int. J. Mol. Sci. 2020, 21(3), 1057; https://doi.org/10.3390/ijms21031057

Arno, B., Galli, F., Roostalu, U., Bashar M Aldeiri, B.M., Miyake, T., Albertini, A., Bragg, L., Prehar, S., McDermott,J.C.,Cartwright, E., and Giulio Cossu G. TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors. J Cell Sci. 2019 Aug 8;132(15). pii: jcs234948. doi: 10.1242/jcs.234948.PMID:31289197

Tripathi, S.,Miyake, T., and McDermott, J.C.Smad7:β-catenin complex regulates myogenic gene transcription.  Cell Death Dis. 2019 May 16th,doi.org/10.1038/s41419-019-1615-0.

Ehyai S, Miyake T, Williams D, Vinayak J, Bayfield MA, McDermott JC.  FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation EMBO Rep. 2018 Dec;19(12). pii: e45536. doi: 10.15252/embr.201745536. Epub 2018 Oct 25.PMID:3036139

Tobin SW, Hashemi S, Dadson K, Turdi S, EbrahimianTobin, S.W., Hashemi, S., Dadson, K., Turdi, S., Ebrahimian, K., Zhao, J., Sweeney, G., Grigull, J., and McDermott, J.C. Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers. Sci Rep. 2017 Jun 30;7(1):4476. doi: 10.1038/s41598-017-04762-x. PMID: 286672502017

 Pagiatakis C, Sun D, Tobin SW, Miyake T, McDermott JC. TGFβ-TAZ/SRF signalling regulates vascular smooth muscle cell differentiation.  FEBS J. 2017 Mar 25. doi: 10.1111/febs. 

Tobin, SW., Yang,D., Girgis, J., Farahzad, A., Blais, A. and McDermott JC. Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy. J Cell Sci. 2016 Nov 1;129(21):4076-4090.

Ehyai S, Dionyssiou MG, Gordon JW, Williams D, Siu KW, McDermott JC A p38 MAPK regulated MEF2:β-catenin interaction enhances canonical Wnt signalling. Mol Cell Biol. 2015 Nov 9.  MCB.00832-15. PMID: 26552705

Mughal W, Nguyen L, Pustylnik S, da Silva Rosa SC, Piotrowski S, Chapman D, Du M, Alli NS, Grigull J, Halayko AJ, Aliani M, Topham MK, Epand RM, Hatch GM, Pereira TJ, Kereliuk S, McDermott JC, Rampitsch C, Dolinsky VW, Gordon JW. A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. Cell Death Dis. 2015 Oct 29;6:e1944. doi: 10.1038/cddis.2015.306.

Hashemi S, Wales S, Miyake T, McDermott JC.Heart disease: recruitment of MEF2 activity by β-blockers wards off cardiomyocyte death. Cell Death Dis. 2015 Oct 15;6:e1916. doi: 10.1038/cddis.2015.293.

S Hashemi, J Salma, S Wales & JC McDermott. Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers.   Cell Death Discov. 2015; 1: 15019.           

Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G. Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy . J Mol Cell Cardiol. 2015 Jul 18. pii: S0022-2828(15)30004-3. doi: 10.1016/j.yjmcc.2015.06.020.PMID: 26196305       

Wales S, Hashemi S, Blais A, McDermott JC.  Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014 Oct;42(18):11349-62. doi: 10.1093/nar/gku813. Epub 2014 Sep 12.

Dionyssiou MG, Ehyai S, Avrutin E, Connor MK, McDermott JC. Glycogen synthase kinase 3β represses MYOGENIN function in alveolar rhabdomyosarcoma.Cell Death Dis. 2014 Feb 27;5:e1094. doi: 10.1038/cddis.2014.58. PMID: 24577092

Belozerov VE, Ratkovic S, McNeill H, Hilliker AJ, McDermott JC. In Vivo Interaction Proteomics Reveal a Novel p38 Mitogen-Activated Protein Kinase/Rack1 Pathway Regulating Proteostasis in Drosophila Muscle.  Mol Cell Biol. 2014 Feb;34 (3):474-84.

Alli NS, Yang EC, Miyake T, Aziz A, Collins-Hooper H, Patel K, McDermott JC. Signal-dependent fra-2 regulation in skeletal muscle reserve and satellite cells. Cell Death Dis. 2013 Jun 27;4:e692. doi: 10.1038/cddis.2013.221.

Dionyssiou MG, Salma J, Bevzyuk M, Wales S, L LZ, McDermott JC Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling. Skelet Muscle. 2013 Apr 2;3(1):7.

Dionyssiou MG, Nowacki NB, Hashemi S, Zhao J, Kerr A, Tsushima RG, McDermott JC.    Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle.  J Mol Cell Cardiol. 2013 Jan;54:35-44. Epub 2012 Nov 5.

Belozerov VE, Lin ZY, Gingras AC, McDermott JC, Michael Siu KW. High-Resolution Protein Interaction Map of the Drosophila melanogaster p38 Mitogen-Activated Protein Kinases Reveals Limited Functional Redundancy. Mol Cell Biol. 2012 Sep;32(18):3695-706. Epub 2012 Jul 16.

Salma J, McDermott JC. Suppression of a MEF2-KLF6 Survival Pathway by PKA Signaling Promotes Apoptosis in Embryonic Hippocampal Neurons. J.Neurosci. 2012 Feb 22;32(8):2790-803.

Pagiatakis C, Gordon JW, Ehyai S, McDermott JC   A novel RhoA/ROCK- CPI-17 -MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.  J Biol Chem. 2012 Mar 9;287(11):8361-70. Epub 2012 Jan 23.

Miyake T, McDermott JC, Gramolini AO.  A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dye. PLoS One. 2011;6(12):e28628. Epub 2011

Chan CY, McDermott JC, Siu KW. Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics.    Int J Proteomics. 2011;2011:329467. Epub 2011

Chan CY, Masui O, Krakovska O, Belozerov VE, Voisin S, Ghanny S, Chen J, Moyez D, Zhu P, Evans KR, McDermott JC, Siu KW.  Identification of differentially regulated secretome components during skeletal myogenesis. Mol Cell Proteomics. May;10(5):M110.004804. Epub 2011 Feb 22. 2011

Miyake T, Alli NS, McDermott JC.  Nuclear function of Smad7 promotes myogenesis.Mol Cell Biol. 30(3):722-35, 2010.

Aziz A, Miyake T, Engleka KA, Epstein JA, McDermott JC. Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages. Dev Biol. 332(1):116-30, 2009

Miyake T, Alli NS, Aziz A, Knudson J, Fernando P, Megeney LA, McDermott JC. Cardiotrophin-1 maintains the undifferentiated state in skeletal myoblasts. J Biol Chem. 284(29):19679-93, 2009

Gordon JW, Pagiatakis C, Salma J, Du M, Andreucci JJ, Zhao J, Hou G, Perry RL, Dan Q, Courtman D, Bendeck MP, McDermott JC. Protein Kinase A-regulated Assembly of a MEF2/HDAC4 Repressor Complex Controls c-Jun Expression in Vascular Smooth Muscle Cells. J Biol Chem. 284(28):19027-42, 2009

Perry RL, Yang C, Soora N, Salma J, Marback M, Naghibi L, Ilyas H, Chan J, Gordon JW, McDermott JC. Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1 a represses MEF2-dependent gene expression. Mol Cell Biol. 29(12):3355-66, 2009

Kollias, HD, and McDermott JC. Transforming growth factor-beta and myostatin signaling in skeletal muscle.  J Appl. Physiol. 104(3):579-87. (Review) 2008

Du M, Perry RL, Nowacki NB, Gordon JW, Salma J, Zhao J, Aziz A, Chan J, Siu KW, McDermott JC. Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D.Mol Cell Biol. 28, 2952-2970, 2008

Eguchi, M., Gillis, L.C., Liu, Y., Lyakhovsky,N., Du, M., McDermott,J.C.,and  Sweeney, G.  Regulation of SOCS-3 expression by leptin and its co-localization with insulin receptor in rat skeletal muscle cells Mol Cell Endocrinol. 267(1-2):38-45. 2007

Chan X.C.Y., McDermott, J.C. and Siu, K.W.M.  Identification of secreted proteins during skeletal muscle development.  J. Proteome Res. Feb;6(2):698-710, 2007

Kollias, HD, Perry, R, Miyake, T., Aziz,A. and McDermott, J.C.Smad7 promotes and enhances skeletal muscle differentiation . Mol Cell Biol. 26, 6248-6260, 2006

Luciana de Angelis, Jianzhong Zhao, John J. Andreucci, Eric N.Olson^‡,Giulio Cossu, and John C. McDermott. Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway.Dev Biol. 283,171-179. 2005.

Cox, D.M., Zhong, F., Du, M., Duchoslav E., Sakuma, T., and McDermott, J.C. Multiple reaction monitoring as a method for identifying protein posttranslational modifications. J. Biomol. Tech. 16, 83-90, 2005